RCRS update 7 April 1997 (file name: 040797.txt) The following quote is from http://www.ivanhoe.com/docs/backissues/shockingcancer.html =====Begin quote on "Electrochemotherapy"================= There's new hope for those who suffer from skin cancer. The research uses electricity to deliver a healing jolt of chemotherapy. Harry Coleman is receiving electric shocks that may save his life. Eight pulses, each 100-millionth of a second, deliver chemotherapy to his skin cancer. The procedure is called electroporation. Here's how it works. Normally chemotherapy surrounds a cancer cell but has trouble breaking through. But with a jolt of electricity, the cells pores open, allowing medicine to enter. Then the cell wall closes, with the chemotherapy trapped and fighting the cancer cell from within. Timing is critical. Richard Heller, Ph.D., Researcher, H. Lee Moffitt Cancer Center: "If the holes open up and the drug is not there it's not going to work, if the drug is there and the holes aren't there, it's not going to work either, so it's important to have those working hand in hand." To make sure the chemotherapy is at the right place at the right time, it's injected directly into the lesion just before the jolt. The caliper electrodes are crude looking but essential to measure the size of the tumor and the amount of the jolt. In this case, 13-hundred volts over a very small area less than an inch. Patients say it's not painful. Dr. Heller and Harry Coleman, Skin Cancer Patient: "How'd that make you feel? Strange?" "Yeah." "Left you speechless?" "Different, different." So far only 35 patients have been tested worldwide, but skin cancers have shown remarkable improvement in as little as four months. Researchers say they're light years away from calling this a cure, but this new electric shock treatment appears to hold much promise. Another advantage for patients is that less chemotherapy is needed. The H. Lee Moffitt Cancer Center in Tampa is the only research facility in this country testing electroporation. Most of the tumors treated so far have been basal cell carcinomas. If you would like more information, please contact: Karen Clarke H. Lee Moffitt Cancer Center 12902 Magnolia Drive Tampa, FL 33612 (813) 632-1353 Click here to order additional research and full length news video. -----------------end quote------------------------------- RCRS Commentary This is the kind of brute force methodology that has always been at the forefront in the old and currently received majority-medical philosophy. Majority does not equate to soundness or correctness. As Dr. Krebs liked to point out, science is not founded on popular plebiscite; and the scientific facts that obtain today were originally almost always a matter of a minority and even singular advocacy. This is in common with the growth of a crystal as well as any dynamic growing system: it has a central nucleus, and expands outwardly. The prior waves of mis-information must pass completely away before the new data is generally recognized and appropriated. Thus almost the entire sphere of medicine today is saturated with a faulty basis for evaluating or comprehending health and disease, and resistant to applying biological principles for both prevention and treatment. Happily, this is steadily and rapidly changing. It is apparently intrinsically difficult for anti-metabolic medical researchers to confront and critically and corrosively examine their philosophy. It seems beyond those currently in positions of authority to set aside the patterns of thinking that they mistakenly associate with scientific method, to open mindedly examine the proofs that show that violent, artificial (patentable) processes are not the "best" hope for addressing the cancer problem or any other disease. The cancer cellular barrier is dissolved by proteo- and glycolytic enzymes, namely the trypsins, and amylase, as was proved over 90 years ago by John Beard and Dr. Lambelle in Scotland, as well as by other doctors elsewhere in the world. This barrier of the cancer cell is referred to as the sialomucinous barrier or glyco-protein barrier. It is an elementary fact that electron-rich mucous surfaces are repulsive to negatively charged molecules. This is one reason, it is believed, that some tests of Laetrile may not have produced the results predicted by theoretical models, and expected by experienced researchers. The scissioned glucoside or glucuronide releases mandelonitrile, composed of cyanide and benzaldehyde which then perfuse the cancer lesion. The cyanide radical is negatively charged, and unless this glyco-protein coat is dissolved, the molecule cannot act in the cell cytoplasm as theoretically predicted. Thus, as in the case of pregnancy trophoblast, the delivery of this -CN radical to the cancer cytoplasm requires the prior action of the pancreatic enzymes. And of course this is one of the vicious circles dealt with in cancer: The clinical cancer evolves on the foundation that the intrinsic factors were not sufficient to de-shield the cancer cell laying it open to attack by the white blood cells or phagocytes (macrophage) and the rest of the immune system cells and certain cellular enzymes. (Laying aside for now the issue of carcinogens, and their own activity as both enzyme inhibitors and focalizing factors of stimulants for trophoblast evolution.) By whatever means these enzymes were deactivated, once they become deficient, nutrition is obviously affected, resulting in inadequate or improper break down of proteins in the diet, thus the essential amino acids that would have been yielded from them cannot be used to synthesize more enzymes, and generally the system begins a downward spiral both in terms of organic structure, negative nitrogen balance, immune strength, and homeostasis generally. The first step then is always to regenerate the intrinsic anti-neoplastic system. This may begin by eliminating any artificial or pathogenic sources of enzyme inhibitors. We've already delineated in earlier RCRS updates that these inhibitors or dissipating sources include diet (heavy reliance on refined sugars and proteins..steroid-rich meat and instant potato diets); heavy metal and other metal ions; preservatives in foods; secretions by parasites; bacteria, etc. to say nothing regarding certain dietary intolerances. Then it is logical to supplement the pancreatic enzymes immediately. As pointed out, experience taught the earliest researchers that this must include the entire gamut of enzymes, not just the proteolytic enzymes. This makes sense because the breakdown products of the cancer process from action by the proteolytic enzymes include polysaccharides, glycogen, fats, nucleic acids, etc. Each breakdown product is then picked up by other enzymes, such as maltase acting on the breakdown products by amylase. The glyco-proteins of the cancer cell require both amylase and trypsin acting together synergistically, the cytoplasmic contents of the trophoblast/cancer are also then released which can then be digested, for example by RNase. The earliest researchers, beginning with John Beard, learned that amylase must be supplemented in quantities double that of the proteolytic components. We now know the reasons for this lie in the nature of the structure of the glyco-proteins, wherein, for example, hCG-Beta/CTP, possess 12 sialic acid side chains for every protein molecule. The cancer cell can probably regenerate these glycoproteins if only one component is acted on, but when both are degraded, the system is severely broached. Depending on the extent of the cancer process, these glycoproteins will certainly involve all available enzyme resources of the host to degrade them. So a high turn-over is likely. Recall that in pregnancy, it takes the dual action of both maternal and fetal pancreatic secretions to curb and eventually destroy placental trophoblasts. And even then the degradation is gradual, and extremely slow. The cancer patient therefore must apply an artificial "fetal" component for pancreatic support in the form of supplemental enzymes and their potentiators. We've studied the methods of several herbalists. Those with some astounding successes in cancer therapy have all used a three step routine: clear and "detoxify" the intestines, liver, spleen, kidneys and skin; Then utilize herbs that act directly on the cancer or support the immune system. The reasons for this are obvious. If you are going to empty a house of pests, you have to clear a path, and stimulate and potentiate the activity of the elimination systems. Then you can drive out the pests, and then get into the house and rebuild it. An apt analogy for carcinogenesis can be found in a parable given by Jesus: before thieves could get in to rob the house, they had to bind the strong-man. The enzyme systems of the body are the "strong-man" in the parable; the bindings are the enzyme inhibitors. While these herbalists may not have known anything about the biochemistry of what they were doing, they obviously understood what works. On that note I recommend readers find a copy of Eli P. Jones, M.D.'s book: Cancer, its causes, symptoms and treatment. This book is a rich source of interesting anecdotes, full of herbal formulas, and poultices which worked. Skin cancers, breast cancers, sarcomas and a wide range of other cancers were successfully treated by Dr. Jones. At some future time we will be analysing the pharmacopeia used by Jones to determine both their nitrilosidic content as well as possible action on pancreatic enzymes, or their inhibitors. Before Dr. Krebs died, we had discussed this kind of study, which would essentially unify all the herbal alternatives under the umbrella of Beardianism, or the trophoblastic basis of cancer. The Beardian researchers also learned from experience that destruction of an advanced tumor must not be too drastic. Rife learned this using his apparatus, and thus the treatment was applied every other day. It is interesting to note that apparently the Rife apparatus may act on reactivating the pancreatic enzymes, as one user noted that the pancreatic enzyme concentration shot up after treatment, to the extent they were concerned about it. So gradual incremental use of any protocol also makes sense, and is commonly practiced in all the best metabolic clinics world-wide. This empirical knowledge has recently been rendered rational through exacting analytical techniques. For example, it is well known that immune-complexes are degraded by supplemental enzymes. This results in the degradation of these complexes with subsequent loading of the anti-gens into the sera, with a temporary exacerbation of symptoms, until further action by these enzymes can degrade the constituents. These are then cleared by the phagocytes or the mono-molecular particles are resorbed. The system literally eats the offending cancers, as well as eliminating them by excretory routes. It may be that because of the internet and the patient's own self-education and the bringing of these facts to the attention of their therapists, that immuno-enzymological, orthomolecular and metabolic therapies will be recognized as logical and effective. If nothing else, through people's own application of these principles, the cancer business will take a dip and the adoption of these proven practices will be accelerated on nothing more than monetary concerns.