[Entrez medline Query] 20 citations found Other Formats: [Citation Format] [MEDLINE Format] Links: [200 medline neighbors] Pharm Weekbl [Sci] 1982 Dec 17;4(6):172-175 Determination of amygdalin and its major metabolite prunasin in plasma and urine by high pressure liquid chromatography. Rauws AG, Gramberg LG, Olling M A method is described for the determination of amygdalin and prunasin in plasma ultrafiltrate and urine. Both compounds are separated by high pressure liquid chromatography on a reversed phase column and subsequently detected at 215 nm. The identity of an amygdalin metabolite with prunasin was confirmed by mass spectrometry. --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [197 medline neighbors] N Engl J Med 1982 Nov 18;307(21):1340-1341 Laetrile. [LETTER] Shils ME --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [88 medline neighbors] J Toxicol Clin Toxicol 1982 Oct;19(8):851-856 The pharmacokinetics of prunasin, a metabolite of amygdalin. Rauws AG, Olling M, Timmerman A The pharmacokinetics of prunasin have been investigated in the dog. The results are compared with results obtained with amygdalin. The volume of distribution and the clearance of prunasin are larger than those of amygdalin. The oral bioavailability of prunasin is approximately 50%, whereas amygdalin is hardly absorbed unchanged. --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [28 medline neighbors] J Anal Toxicol 1982 Sep;6(5):244-246 Methodology for the detection and measurement of amygdalin in tissues and fluids. Balkon J Methods suitable for the demonstration of amygdalin are presented; including an indirect determination (measurement of enzymatically derived benzaldehyde) and several direct methodologies (GC/MS, HPLC, or TLC). Reagents and equipment commonly found in a forensic toxicology laboratory were employed. --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [200 medline neighbors] N Engl J Med 1982 Jul 8;307(2):118-120 Laetrile. [LETTER] --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [64 medline neighbors] Mt Sinai J Med 1982 Jul;49(4):305-307 Near fatal laetrile intoxication: complete recovery with supportive treatment. Lee M, Berger HW, Givre HL, Jayamanne DS --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [93 medline neighbors] Cephalalgia 1982 Jun;2(2):111-124 Foods, and food and drug combinations, responsible for head and neck pain. Seltzer S The literature has been reviewed to uncover the existence of head and neck pain syndromes caused by foods and food and drug combinations. Knowledge of the etiology of such syndromes may help in their treatment. At least twenty-five syndromes have been described. These include those induced by coloring and flavoring agents, alcoholic products, chocolate, coffee and tea, foods containing tyramine, vitamins, minerals, pesticides, and several others. Where possible, the active ingredients and the minimal amounts responsible for the induction of pain have been identified. --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [109 medline neighbors] Bull N Y Acad Med 1982 Apr;58(3):323-340 Unproved dietary claims in the treatment of patients with cancer. Shils ME, Hermann MG --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [200 medline neighbors] N Z Med J 1982 Mar 24;95(704):184-185 A verdict against laetrile. [EDITORIAL] --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [109 medline neighbors] Science 1982 Mar 19;215(4539):1513-1515 Congenital malformations induced by laetrile. Willhite CC Laetrile administered orally ot pregnant hamsters caused skeletal malformations in the offspring, but intravenous laetrile filed to result in embryopathic effects. Oral laetrile significantly increased in situ cyanide concentrations, while intravenous laetrile did not. Thiosulfate administration protected embryos from the teratogenic effects of oral laetrile. The embryopathic effects of oral laetrile appear to be due to cyanide released by bacterial beta-glucosidase activity. --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [129 medline neighbors] Arch Toxicol 1982 Mar;49(3-4):311-319 The pharmacokinetics of amygdalin. Rauws AG, Olling M, Timmerman A Amygdalin (D-mandelonitrile-beta-D-gentiobioside) is a cyanogenic glycoside claimed to show anti-cancer activity, sold under the incorrect name "Laetrile". For a sensible discussion of its alleged activity and its established toxicity it is necessary that its fate in the organism is known. The pharmacokinetics of amygdalin have been investigated in the Beagle dog after both intravenous and oral administration. The excretion of amygdalin has also been studied in the rat. Amygdalin concentrations were determined by high performance liquid chromatography in plasma ultrafiltrate and urine. The pharmacokinetics of amygdalin after intravenous administration were compared with those of diatrizoate, a model substance for extracellular volume and glomerular filtration. The amygdalin clearance is significantly larger than that of diatrizoate. The volumes of distribution of both substance are the same. After oral administration only a few percents of the amygdalin dose are systemically available. A part of the oral dose is recovered from the urine as prunasin (D-mandelonitrile-beta-D-glucoside). --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [163 medline neighbors] J Dent Res 1982 Mar;61(3):502-505 Regulation of the growth rate of Streptococcus mutans. Cuffini A, Kral TA, Daneo-Moore L Streptococcus mutans strain GS-5 was grown under a variety of environmental conditions in order to achieve different balanced growth rates. A range of growth rates could be obtained using limitations in the concentrations of glutamate/glutamine, leucine, or valine. Different balanced growth rates were also obtained when cells were grown in a variety of carbon sources. Using glucose, cellobiose, amygdalin, maltose, mannitol, and galactose, reproducible doubling times were obtained ranging from 61 to 226 min. --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [198 medline neighbors] N Engl J Med 1982 Jan 28;306(4):236 Closing the books on Laetrile. [EDITORIAL] Relman AS --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [161 medline neighbors] N Engl J Med 1982 Jan 28;306(4):201-206 A clinical trial of amygdalin (Laetrile) in the treatment of human cancer. Moertel CG, Fleming TR, Rubin J, Kvols LK, Sarna G, Koch R, Currie VE, Young CW, Jones SE, Davignon JP One hundred seventy-eight patients with cancer were treated with amygdalin (Laetrile) plus a "metabolic therapy" program consisting of diet, enzymes, and vitamins. The great majority of these patients were in good general condition before treatment. None was totally disabled or in preterminal condition. One third had not received any previous chemotherapy. The pharmaceutical preparations of amygdalin, the dosage, and the schedule were representative of past and present Laetrile practice. No substantive benefit was observed in terms of cure, improvement or stabilization of cancer, improvement of symptoms related to cancer, or extension of life span. The hazards of amygdalin therapy were evidenced in several patients by symptoms of cyanide toxicity or by blood cyanide levels approaching the lethal range. Patients exposed to this agent should be instructed about the danger of cyanide poisoning, and their blood cyanide levels should be carefully monitored. Amygdalin (Laetrile) is a toxic drug that is not effective as a cancer treatment. --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [169 medline neighbors] West J Med 1982 Jan;136(1):65-69 Cyanide poisoning after bitter almond ingestion. Shragg TA, Albertson TE, Fisher CJ Jr --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [182 medline neighbors] Appl Environ Microbiol 1982 Jan;43(1):86-89 Isolation and characterization of new strains of cholesterol-reducing bacteria from baboons. Brinkley AW, Gottesman AR, Mott GE We isolated and characterized nine new strains of cholesterol-reducing bacteria from feces and intestinal contents of baboons. Cholesterol-brain agar was used for the primary isolation, and subsequent biochemical tests were done in a lecithin-cholesterol broth containing plasmenylethanolamine and various substrates. All strains had similar colony and cell morphology, hydrolyzed the beta-glucosides esculin and amygdalin, metabolized pyruvate, and produced acetate and acetoin. Unlike previously reported strains, the nine new strains did not require cholesterol and an alkenyl ether lipid (e.g., plasmalogen) for growth; however, only two strains reduced cholesterol in the absence of the plasmalogen. These two strains also produced succinate as an end product. Carbohydrate fermentation was variable; some strains produced weak acid (pH 5.5 to 6.0) from only a few carbohydrates, whereas other strains produced strong acid reactions (pH less than or equal to 5.5) from a wide variety of carbohydrates. --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [200 medline neighbors] JAMA 1981 Dec 18;246(24):2841-2842 Laetrile-induced agranulocytosis. Liegner KB, Beck EM, Rosenberg A --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [143 medline neighbors] Can Med Assoc J 1981 Nov 15;125(10):1126 Deliberate self-poisoning with Laetrile. Moss M, Khalil N, Gray J --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [137 medline neighbors] CA Cancer J Clin 1981 Nov;31(6):365-369 Taking laetrile: conversion to medial deviance. Vissing YM, Petersen JC For members of the CCS, laetrile use occurs in a self-help social context where users derive substantial social and emotional support from fellow members. We are convinced that much of the appeal of laetrile results from this social context in which it is frequently used. The CCS and the extensive network of similar organizations are fulfilling unmet needs in cancer patients and those fearful of cancer. Until conventional cancer therapy deals more successfully with the social and psychological needs of cancer patients, promoters of laetrile will till fertile ground. --------------------------------------------------------------------------- Other Formats: [Citation Format] [MEDLINE Format] Links: [200 medline neighbors] Psychol Rep 1981 Oct;49(2):629-630 Attitudes toward laetrile in relation to death anxiety and experience with cancer in the family. Salter CA, Templer DI --------------------------------------------------------------------------- the above reports in format. ---------------------------------------------------------------------------