Presented by THE ROBERT CATHEY RESEARCH SOURCE http://www.europa.com/~rsc --------------------------------------------------------------------------- The story of Laetrile has few more dramatic successes than in the case of lung cancer. The case histories of the late Dr. John Richardson in treating cancer of lung and metastasized cancer to the lung were very good. He utilized the metabolic protocol, including pancreatic enzymes, amygdalin, amino acids, high potency vitamins and minerals supplements, high dose retinoic acid (synthetic and emulsified or emulgated vitamin A to avoid the liver), high dose vitamin C, and of course vegetarian diet, high in raw and fresh vegetables and fruits and seeds. No meat, no tobacco, no coffee, no alcohol, not even chocolate...leaches minerals. Dr. Philip Binzel can still be consulted, who uses basically the same protocols and whose results in a conservative estimate are 285% better than standard modalities in terms of life extension in his patients. The name of his book, and phone number and that of other metabolic physicians is appended at the end of this post, along with a partial bibliography. This paper is otherwise not referrenced. We are preparing a description of an ideal rigorous protocol for publication on our web site that will be referrenced, but in the mean time these observations may be of help: One thing certainly stands out: in every case of cancer pancreatic enzymes are depressed. And as has also been proven true: whenever a deficiency in function in one area is found in an organ, other functions are often deficient as well. So it is not surprising to find a higher cancer incidence correlation in diabetics than in the rest of the population. Pancreatic enzymes are essential and central to the normal metabolically mediated control and destruction of the cancer cell. Research has proven a correlation between chromium deficiency and the decreased effectiveness of insulin as well as the digestive enzymes of the pancreas. The insulin function is an endocrine function, while the secretion of enzymes are referred to as exocrine functions. That the functional products are both dependent on the mineral cofactor chromium further clears up yet another aspect of metabolic disorder that attends both diseases: diminished amino-acid metabolism. Because it has been found that insulin assists in the delivery of amino acids to tissues and into cellular systems. This further explains the decline in the exocrine function, since the exocrine pancreas can only synthesize the digestive enzymes when adequate amino acids are delivered. And chromium potentiates this function of insulin. Thus the pancreatic deficiency becomes a vicious circle with very broad consequences. Various reports are circulating that supplemental insulin dependency can be dramatically reduced by satisfying the body's demand for chromium. In experimental settings, when chromium is dialyzed out of the blood, it has been found that trypsin is only 5% as effective. When the chromium is returned, the enzymes regain their degrading power. These findings were proven in the 1950s in European labs. It was therefore concluded that chromium is a functional cofactor of trypsin, one of the primary proteases or proteolytic enzyme which is essential for the digestion of proteins..including those in the cancer cell. Trypsin is merely one member of a group of proteolytic enzymes secreted by the pancreas, and they all play a role in the degradation and destruction of cancer, along with the glycogen-digesting enzyme amylase. So important is the pre-action of these enzymes towards the resolution of cancer and other disease systems, that the exocrine pancreas can justifiably be termed as the front line in the immune process. Because not even the phagocytes--or macrophages--can approach the cancer cell until these enzymes are permitted to do their work, due to an immune-cell repulsive coating around the cancer cell. The best absorbed form of chromium is hexavalent chromate, which is metabolized into tri-valent chromium or Glucose Tolerance Factor. Rich sources of biologically active chromium are brewers yeast and black pepper, as well as other readily available foods. A super chromium brewer's yeast is now manufactured for this biologically active metal. When an enzyme degrades or breaks down a substance, the substrate, it's called lysis. In the early 1900s, Dr.s Mendell and Blood found that hydrogen cyanide in the presence of proteolytic enzymes extended and accelerated the activity of proteolysis as much as 300% and more. At that time it was not known that hydrogen cyanide could be delivered in a metabolically non-toxic fashion from common food sources. In the 1950s, Ernst T. Krebs, Jr. positively correlated the intake of nitrilosides (hydrogen cyanide bearing compounds found in many foods, mostly seeds) with lower cancer incidence amongst aboriginal populations. Later, Dr. Harold Manner and even the Memorial Sloan-Kettering proved the anti-neoplastic action of nitrilosides in rats and mice. Although the MSK later recanted, the findings of Mendel and Blood alone suffice to show a functional role for nitrilosides as a cofactor in the proper function of pancreatic enzymes, just as chromium is. But later Dr. Manner and other clinicians proved the effectiveness of amygdalin in human cancer. There are several papers in the RCRS Cancer index which delineate some of these historical and clinical facts which go to prove that along with chromium and other essential cofactors, nitrilosides are functional cofactors as well. For this reason the Krebses' and their associates proposed these natural accessory food factors as a member of the B vitamins or B-17, along with B-12, which also carries a nitrile or cyanide as it's central molecule. Thus research has shown that the numerous problems associated with cancer as well as the cancer itself, are symptoms of specific as well as broad-scaled nutritional deficiencies, which formerly have often been grouped as merely "paraneoplastic syndromes", rather than etiologically or cause-related factors. Without an unifying principle to illuminate the nature of the deficiencies, the universe of diverse facts surrounding cancer might easily be trivialized or be inscrutable. Interestingly, many so-called paraneoplastic syndromes relate directly to pancreatic function. Consider the role of magnesium and it's deficiency, which researchers around the world recognize as having catastrophic consequences in heart disease: trypsin is secreted by the pancreas in inactive form. An enzyme called enterokinase (or enteropeptidase) is required to activate trypsin (trypsinogen) and other enzymes secreted as inactive from the pancreas and referred to as "zymogens". It is now believed that the fall-off in the function of this intestinal activating enzyme is directly related to magnesium levels, as well as aging. But magnesium by itself will activate trypsin, and therefore is an important adjunct not only in the elderly who are the most frequent victims of cancer, but as an important cofactor in clinical intervention in cancer. Magnesium is thought to be essential in the activity of at least 70 different life-sustaining enzymes in our bodies, and probably more. The arrested development of certain white blood cells may be due to a deficiency of trypsin, which I am told has been shown experimentally to promote maturation of developmentally-arrested leukocytes. That the immune system functions only after the peri-cellular coating is digested away from the cancer membrane is well established; if this leukocyte development function can be fully confirmed, the pancreas must then be termed an immune organ along with bone marrow and the thymus. Thus the complete metabolic protocol for cancer must always include the pancreatic enzymes, especially amylase, whose role is to shear away the surgery side chains attached to the proteins, and which give the cancer cell it's strong negative charge that repulses the white blood cells; trypsin, which degrades the proteins along with carboxypeptidase and chymotrypsin; and later ribonuclease which degrades the cancer genome, and lipase and probably all the other enzymes secreted by the pancreas, and which enter the entero-pancreatic circulation. (In multiple-myeloma, amylase may not be required, as titers are usually high, while trypsin is inhibited, thus proving both enzymes are required for successful resolution). There is strong empirical evidence that there is an absorption not only of the intrinsic pancreatic enzymes back into the blood and lymph, but also enzymes derived from our foods or supplements, as much as 40% according to Dr.s Lopez, Williams, and Mielhke. The principal concept is that cancer cells actually elicit pancreatic proteases and amylase by their presence, just as food in the stomach stimulates pancreatic secretion by means not fully understood. A deficiency in either amylase or the proteases would be disastrous if continued unsatisfied. The delivery of the essential amino acids, chromium and magnesium (as well as zinc) insure that the pancreas will synthesize these enzymes in sufficient quantity to satisfy both intestinal digestion, and the immuno-enzyme function against the cancer cell or parasites. Supplemental enzymes at least insure that proteins delivered to the stomach and intestines will go towards further synthesis. Supplemental amino-acids are also utilized in the best metabolic clinics. But as I said, research indicates there is reabsorption of endogenous, and absorption of exogenous enzymes, if not other macromolecules, which will bolster the intrinsic enzymes by way of the entero-pancreatic circulation. In many cases the only possibility of hope is direct injection of amylase and trypsin into the blood stream or lymph channels, as well as directly into the solid tumor or lesion. The programs variously used follow closely the subjective responses, as well as presenting symptoms. In most cases daily injections have been well tolerated historically, but some clinics that utilize parenterally administered enzymes allow a day of clearance between injections. In lung cancer, the injection of the nitriloside amygdalin is especially potent as it goes directly to the right heart, thence to the lungs and avoids the liver altogether, where the hydrolized molecule may be metabolized into less active form. Even after metabolization, however, the thiocyanate metabolite will accelerate proteolysis. Fundamentals What is the unifying principle then? Cancer cells are normal cells to the life cycle, and their principal role is in pregnancy as the origin of the placenta, amnion and chorion both, wherein they are known as trophoblasts. Thus they are equipped with several defensive maneuvers to survive in the autonomous role they play in the fetal nutrition. They are a potentiality of the totipotent or "individual" cell, the germ cell, originally activated by sex steroids. And after they develop, they also secrete hormones and steroids for their further development and preservation. The mother reacts to this canalized cancer system, or the trophoblasts by secreting digestive enzymes. The trophoblast must defend itself against these enzymes, and so it secretes inhibitors which deactivate these enzymes. A similar mechanism is used by pin and round worms like Ascaris, and other parasites. The chorionic trophoblasts succeed at this inhibition for about 8 weeks, when there is a sudden fall off in the activity of the invasive and metastasizing trophoblast (cytotrophoblast). Why? At the 8th week, the fetal pancreas begins to function, and so it contributes proteolytic enzymes to the degradation of the diffusing hormones or proteins of the cancer-trophoblast system. Still, it takes a further 28 weeks of continual, daily enzyme action to fully control and destroy the trophoblasts. Actually the cancer (trophoblast) cell first becomes transformed by these enzymes into a non-dividing, steroid producing phase, which corresponds to so-called benign, non-proliferating, or non-dividing cancer, or syncytial processes. They still expand slightly by actually fusing with the contiguous somatic elements or normal cells of the mother's uterus, which results in multi-nucleated, highly vascularized cellular processes. If the pancreatic enzymes don't actually over-balance the output of the enzyme-inhibitors of the trophoblasts, the former cyto-trophoblast can re-arise, with powers of division and metastasis and then you have a fulminating chorionepithelioma, the deadliest cancer there is. Thus the complete degradation of the trophoblasts of pregnancy represents a complete "regression" in cancer. Every living human being represents a conquering of cancer. And after birth not one such trophoblast is left alive in the infant's body. Trophoblast is the origin of the entire placenta, but does not become incorporated into the living form. But various competent cells do exist within us, male and female, that can evolve into trophoblast and not just germ cells. It invariably begins with estrogen or an estrogen-like carcinogen. The hybridization of trophoblast with the tissues of the primary site is what gives the wide variety of types of cancer. But trophoblast is the constant malignant component, as is proven by the several proteins expressed by cancer which are shared only with trophoblast. Inhibitors The commonest enzyme inhibitors might be running out of your tap: heavy metals like copper, mercury and silver. They are certainly ubiquitous in the industrialized environment. But even sweet potatoes and soy beans, not properly cooked, can inhibit trypsin. We aren't certain, but we believe canola or rape-seed oil, one of the most processed oils on the market, may inhibit trypsin and possibly lipase, tests are under way. Margerine can foul up the works, so butter is preferred. Organic foods are of course best. The organophosphates commonly used in pesticides are amongst the most powerful of the inhibitors, broadly referred to as serpins. For heavy metals, N-acetylcysteine, EDTA, and other chelators are important clinical innovations for getting them out of the system. If chelation is resorted to, there must be followed a rigorous repletion program for calcium, chromium, magnesium and zinc especially, as these are essential for enzyme attachment and optimal conformation in degrading the cancer-membrane-substrates. Orotates are the preferred organic-metals, but for chromium, yeast-GTF, or tri-valent chromium-nicotinate. As mentioned, intestinal parasites like ascaris secrete trypsin inhibitors, and so pains should be taken to follow some anti-parasitical protocols. Laetrile or amygdalin is believed to be a good parasiticide, vermifuge or anthelmintic. Ficin was shown to dissolve ascaris even when trypsin failed to do so (ficin is derived from fig sap, is used diluted, and is found to some extent in yellow figs). Papain and bromelain together with fig-factor and nitrilosides are bound to purge many parasites. Vitamin A has been noted to be essential for normal differentiation of epithelium, which by far is the most frequent tissue target for cancer evolution. Vitamin A deficiency leads to squamous cellular processes, and metaplasia, which is frequently observed to be a precursor in cancer evolution. Beyond that, it has been noted that amongst the side-effects of retinoids (primarily synthetic retinoids, due to the toxicity of natural analogs) is a weakening of the lysomal membranes in the cancer cells, which can lead to autolysis or slow the cancer cell down at least, since the movement of these internal enzymes to the outside of the cancer cell for destruction of tissues might be more difficult if the membrane is fragile. Clinical experience shows that as high as 500,000 units of emulsified vitamin A is well tolerated if gradually introduced. The experience with immuno-enzyme therapy and vitamin A is probably the most well documented in European clinics. Megadoses of vitamin A were observed to stimulate the immune response, cellular antibody formation especially. Some of the side effects of this in conjunction with enzymes are inflammatory reactions of latent infections, but they normally subside in 2 or 3 days. That's it. As short as can be said without leaving out essential facts. Here is a list of metabolic physicians some of whom satisfy every point of this outline. Remember, if a trained physician is a fool to treat himself....what to say of the untrained? Get expert help. Expert and experienced metabolic physicians. Don't make any mistake. ------------------------------------------ Dr. Binzel - Philip E. Binzel, Jr., M.D. 667 Waverly Dr. Washington Court House, OH 43160 (614) 335-2974 -------------------------------------------- Hans Nieper, M.D. 21 Sedan Strasse 3000 Hanover 1 Germany Tel: 011-49-511-348-0808 Fax: 011-49-511-318-417 Doctor Laetrile Researcher, Physicist. --------------------------------------------------------- OASIS Hospital Dr. Francisco Contreras M.D. Director General Paseo Playas de Tijuana No 19 Playas de Tijuana B.C. 22700 Mailing Address: P.O.Box 439045 San Ysidro Blvd., CA 92143 Tel. 1-800-700-1850 1-888-700-1850 Hospital Direct: 011-52-66-80-18-50 Alex: Marketing Director, Stats. --------------------------------------------------------------- Atkins Center 152 E. 55th St. N.Y., N.Y. 10022 212.758.2110 212.754.4284 (fax) Run by Dr. Atkins, M.D. Metabolic, Laetrile, Pancreatic enzymes, you name it. ------------------------------------------------------------ Dr. J. Wright, M.D. Tahoma Clinic in Kent, Wash., 206-854-4900. Metabolic, not specifically for cancer. Hormone replacement therapy, etc. --------------------------------------------------------------- Nicholas J. Gonzalez, M.D. 36A East 36th Street, Suite 204 New York, NY, 10016 Tel: 212-213-3337 Fax: 212-213-3414 Kelley protocol (enzyme therapy, vegetarian, coffee enemas, etc.) Not a Beardian, apparently. ----------------------------------------------------------------- Michael O'Brien, Ph.D., Compounder 1-406-549-9151 Masoula, Montana Has salve for radiation burns ----------------------------------------------------------------- R.S. Organic Imports, Inc. 60 Clinton St. North Tarrytown, N.Y. 10591 Organic Apricot Seeds ----------------------------------------------------------------- Cyto Pharma D.E. Mexico S.A. Lab: 011-52-66-80-42-50 Fax: 011-52-66-33-57-85 Email: b17@telnor.net (Gustavo Del Rio,Jr.) Makers of amygdalin -------------------------------------------------------------- Dr. Joseph Gold, Ph.D. Syracuse Cancer Research Institute Presidential Plaza 600 East Genasee Street Syracuse, New York 13202 U.S.A. Phone: (315) 472-6616 Hydrazine sulfate Research http://www.ngen.com/hs-cancer/ http://www.ngen.com/hs-cancer/article-list.html -- Distributor of Hydrazine Sulfate Great Lakes Metabolics 1724 Hiawatha Court North East Rochester, Minnesota 55904 U.S.A. Phone: (507) 288-2348 ----------------------------------------------------------------- Alpha Omega Box CB 13039 · Nassau, BAHAMAS Phone Center: (809) 356-2093 Fax: (809) 356-2095 Escharotics, I think. ---------------------------------------------------------------- American Biologics--Mexico Hospital and Medical Center Tijuana, B.C., Mexico International Admissions Office 1180 Walnut Avenue Chula Vista, CA 91911 800.227.4458 Formerly Beardians, now not sure what they think. -------------------------------------------------------------- Bio-Medical Center 615 General Ferreira P.O. Box 727 Colonia Juarez, Tijuana, B.C. Mexico (52)84-9011, or (52)814-9132 (Taken from Alternative Health MAgazine, the last phone number looks in error, and might be: (52)84-9132.) This I believe is the old Hoxsey Center ------------------------------------------------------------ American Media G.Edward Griffin, President P.O.Box 4646 Westlake Village, California 91359 1-800-282-2873 Books: World Without Cancer, Griffin Alive and Well, Dr. Binzel Little Cyanide Cookbook, de Spain ---------------------------------------------------------------- International Society of Cancer Victors and Friends They take calls from 9:30a to 1:00p 1-310-822-5032 Grace Moore, IACVF, alternate 1-404-448-4094 ---------------------------------------------------------------- Cancer Book House, a division of the CancerControl Society 2043 N. Berendo Los Angeles, CA 90027 Their phone number is: (213) 663-7801. Bibliography: The Enzyme Treatment of Cancer and its Scientific Basis, John Beard, RCRS $25 Paper bound, double pages, cloth tape spine. Laetrile Case Histories, John Richardson, M.D. and Patricia Griffin, R.N. Out of print, copies available in bound format from RCRS. The collected monographs of Ernst T. Krebs, a few available on the RCRS web site: http://www.europa.com/~rsc Alive and Well, Dr. P.Binzel, M.D. over 25 years as a metabolic physician. American Media Press, see above. Chromium in Nutrition and Disease, Gunay Saner, M.D., Alan R. Liss, NY 1980 Metabolism of Trace Metals in Man, Vols I & II, CRC Press, 1985 The Magnesium Catastrophe Web site: http://www.execpc.com/~magnesum Proteolytic Enzymes and Megadoses of Vitamin A in Cancer Therapy, Wolf, Maehder, Pinoci, Ransberger, Weigelt and Westrick, Mexican Cancer Congress, Sept 30, 1971, Mexico City. Principles of Biochemistry, Second Edition, Lehninger, Nelson and Cox, 1993. Journal of Biochemistry Web site:http://202.252.216.2/jb/biochemi.html Nutrition and Cancer (Current Concepts in Nutrition: vol.6) Myron Winick, ed. Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, John Wiley & Sons. 1977 Nutrition, the Cancer Answer, Maureen Salaman, Statford Publishing, 1984. Cancer, Metabolic Therapy, and Laetrile, Douglas Heinsohn, out of print, copies available on request from RCRS. Good appendix on papers, monographs. Trophoblastic Neoplasia, Toshio Hasegawa, M.D., Williams & Wilkins Co., 1971. Glycoproteins of Blood Cells and Plasma, Jamieson and Greenwalt, eds. J.B.Lippincott, 1971 Freund, E. (and Kaminer), Biochemische Grundlagen der Carcinomdisposition, Wien, Springer, 1925 Immunobiology of Transplantation, Cancer and Pregnancy, Prasanta K. Ray, ed. Pergamon Press,1983 Cancer Cytogenetics, Sverre Heim, and Felix Mitelman, Alan R. Liss, N.Y. 1987. The Beast in the Belly, Dr. Sherwin B. Nuland, M.D., Discover, February 1995 (Excellent writer, great tale about clostridium, trypsin inhibition and NDEs! all in one) Cancer, A Problem in Developmental Biology, Pierce, Shikes and Fink, Prentice-Hall, 1978. Pathophysiology of endoparasitic infection, L.E.A. Symons, Academic Press, 1989. --------------------------------------------------------------------------- The ROBERT CATHEY RESEARCH SOURCE. All pages Copyright © 1996 R.S.Cathey, except where specified otherwise.