http://www.europa.com/~rsc/cancer/013097.txt RCRS Update 30 January 1997 The following is from Cancer Biotechnology Weekly: =========begin quote================== "Life supporting hormone may advance growth of cancer. "A hormone found in the cells of the placenta, which helps sustain pregnancy by protecting an embryo from it's mother's immune system, may also be the biological common denominator among cancers that has eluded scientists for decades, according to a study in the October 1995 issue of the Journal of Cancer. "Human chorionic gondadotropin (hCG), a hormone expressed by all malignant tumors, shields cancerous cells from the immune system's attack, rendering the body defenseless against the advancement of cancer, said Hernan Acevedo, Ph.D., a scientist at the Allegheny-Singer Research Institute (ASRI), Pittsburgh, Pennsylvania, and professor of pathology at the Medical College of Pennsylvania and Hahnemann University, Philadelphia, Pennsylvania. "According to William Regelson, M.D., professor of medicine at the Medical College of Virginia Hospitals - Virginia Commonwealth University, Richmond, the presence of hCG in cancer cells cannot be ignored. "Based on the work of Acevedo and his associates, we must continue to ask why human reproduction and cancer are paradoxically inseperable...there is ample evidence that part of hCG's role in cancer is the same as that in the fetoplacental unit, that is, to make a cell immunologically inert," Regelson states in an editorial accompanying Acevedo's Cancer article." -snip- ..... Cancer Biotechnology Weekly, Oct 30, 1995 p10(2). Subjects: Cancer - Endocrine aspects Chorionic gonadotropin - Therapeutic use ===========end quote=================== The report referred to can be found in Cancer 76(8):1467-75, Oct 1995. One can also read Dr. Regelson's fine introductory essay (pages 1299-1301), in which he mentions John Beard and Dr. Charles Gurchot's review of Beard's work. The late Dr. Ernst T. Krebs, Jr., Director of the Beard Memorial Foundation in San Francisco, and who did more to establish the trophoblastic facts of cancer than anyone else in this century, was Gurchot's student, associate and friend. But he is not mentioned anywhere by Acevedo or anyone else commenting upon Acevedo's findings. The above quote from Ca.Biotech.Weekly makes it out as if these are new findings. This update is only to remind our readers that the referrences in Dr. Kreb's works are replete with the prior established facts concerning the presence of hCG/CTP (the specific cytotrophoblast hormone) in all cancers. Dr. Krebs' and other's work may obviate the necessity or even the wisdom of attacking the cancer problem by anti-body adaptations to hCG in resolving the problem of cancer. Since the problem revolves around the first action of available enzymes to potentiate existing immune components. Dr. Krebs was not bitter about the lack of recognition. His thoughts were on the suffering cancer patient, although he also loved his science. He was perfectly delighted at the indirect means of acknowledgement. It couldn't have been better than to have independent confirmation. Most of the facts martialed by the Krebses regarding the true nature of cancer were established by independent researchers who had not the slightest interest or knowledge of Beard or the Krebses (father and son). The other facts attendent to such a recognition in hCG as "the specific cancer biomarker" are inescapable, and it's only a matter of time before the metabolic protocols are universally acknowledged as the first option applied rather than the last. It was gratifying therefore to learn from Dr. Krebs that he had received a call from the senior editor of a major medical and research journal after Acevedo's findings were published, acknowledging to him that he was all but openly confirmed. It was only a matter of time. Apparently that was good enough for Dr. Krebs, and he quietly left the world in September of last year [1996]. In fact only a matter of hours apparently after our last conversation. A true victor after fighting the good fight. With all due respect to Dr. Acevedo, his obligatory hesitance in proffering that "we cannot cure cancer" might not stand had the prior established facts of many independently confirmed cancers undergoing remission after application of metabolic protocols alone been properly allowed publication and peer review. By metabolic protocols of course we mean the specific use of antithetical-to-trophoblast pancreatic enzymes acting on the cancer's pericellular sialomucinous coatings, with subsequent lysis of their interiors and thereby provision of access by the macrophage and other immune bodies, as well as dietary anti-neoplastic cytotoxins. (It must be reiterated here that use of proteolytic enzymes alone is not in harmony with these facts, either. For the complete lysis of the cancer/trophoblast calls upon the action of carboxypetidase, amylase, the erepsins, and of course, the trypsinogen activating intestinal enterokinase or in it's stead magnesium chloride for example.) The cytotoxins used were the cyanophoric glycosides, either as apricot kernals yielding amygdalin, a beta-glucoside, or the synthetic form Laetrile (laevo-mandelonitrile-beta-glucuronoside), usually both, on alternate days. Their role cannot be ignored, either, as playing a major role in these remissions. Several cases have come to my attention where the protocol was ingestion of apricot seeds alone. As anecdotes, however, they do not satisfy the requirments for scientific rigour. But the chemistry or biochemistry alone cannot be disregarded. For those interested in general reading on this subject, we recommend Dr. Philip Binzel's book "Alive and Well--One Doctor's Experience with Nutrition in the Treatment of Cancer Patients". The book is available from American Media for $9.95. (Box 4646, Westlake Village, Calif. 91359, or call 1-800-282-2873; Same number for fax on weekends). Dr. Binzel is an M.D. who has used Laetrile for over 20 years. His statistics show that his protocols delivered 287% better results for life extension than the usual protocols used in the medical community at large. He used a period of 18 years to examine this life extension for 108 patients with 23 different types of cancer that had metastasized. 76 did not die of their disease(70.4%); he then included 9 who died of unknown causes as theoretically dying of cancer to adjust this figure down to 62.1% to arrive at the differential between his protocols and that of standard practice. 287% better results is thus the conservative estimate. Acknowledging that cancer is trophoblast, and acceding to the biological facts concomitant with the trophoblastic environment, the rationale for nitrilosides is based on the following grounds: the contiguous soma's mode of detoxification of the cancer steroidal secretions is a counter secretion of beta-glucuronidase (BG) to yield, for example, beta-estrogen-glucuronoside. The nitriloside Laetrile has an obvious specificity for the cancer environment (while the dietary form must be metabolized to form a glucuronoside after oxidation; or by glucuronic acid conjugation) since the molecule will be unlocked in the presence of B.G. Hydrogen cyanide is released along with benzaldehyde. Both powerful cytotoxins for the cancer cell; while both are easily detoxified by normal cells. For nitrilosides to successfuly perform as cancer-cytotoxins, there must be prior deshielding of the cancer's pericellular sialomucin, since the cyanide radical is negatively charged in kind with this electron-rich sialoglycoprotein. In trials where laetriles failed, there may have been a severe depression or inhibition of the pancreatic enzymes; or the laetrile was inert by being the wrong isomer form. But furthermore, and perhaps most importantly, steroid production is the role of syncytiotrophoblast, the non-metastasizing trophoblast tissue which is differentiated from cyto-trophoblast, the invasive, corrosive and malignant component of all cancers. Cytotrophoblast is induced to this differentiation by factors extrinsic to itself. It is not genetically programmed to become the steroid-producing and benign form. These extrinsic factors are the pancreatic enzymes. It follows that prior action is required of the pancreatic enzymes. Syncytial trophoblast is the benign component, and it does not secrete hCG-beta, but it does the steroids necessary for the preservation of the uterine decidua. Therefore syncytial trophoblast is sometimes called the "placental pituitary". Again, the body's detoxifying secretions of BG which unlock the nitriloside into it's cytotoxic moiety of benzaldehyde and cyanide requires the prior action of pancreatic enzymes. Specifically carboxypeptidase, trypsin, chymotrypsin, and amylase; while the other serine enzymes will play a role in complete resorbtion and metabolization of the products of this lysis. Amylase is probably the most important first acting enzyme, because by it's action the electron-rich carbohydrate portion of the membrane is stripped away, carrying with it the terminal sialic acids. But the nitriloside's role is not limited to being a cytotoxin: in any environment in which beta-glucuronidase may be found--liver, intestines, kidneys--their action on this substrate with subsequent release of hydrogen cyanide acts to synergistically accelerate proteolysis wherever proteolytic enzymes may be found. (See Vines, Annals of Botany, 42, p.606, 1903; Mendel and Blood, J.Biol.Chem. Vol.8, p.180, ff. 1910-11). Thus nitrilosides are proteolytic enhancers, or potentiators. In any case, the one essential ingredient will always be the pancreatic enzymes. They are the sine qua non of cancer resolution. This synergistic effect of HCN was noted mostly for plant derived proteolytic enzymes, especially the papain complex. But this papain is noted for tryptic and peptonizing components. The end effect will be the same: the total serum content of proteolytic enzymes will either unburden the specific serine proteases to act on the cancer, or they will act synergistically together to break down the d-glyco-proteins of the cancer, whether cyto- or syncytiotrophoblast. As an interesting aside: this acceleration property of HCN was discovered serendipitously when chemists sought some antiseptic to insure the purity of their reagents. Proteolysis was found to be remarkably accelerated when HCN was used, while sodium fluoride and chloroform inhibited complete proteolysis. For a time HCN was displaced in laboratory work by sodium fluoride and chloroform as antiseptics, out of fear no doubt of gaseous cyanides' lethality. Sodium fluoride inhibits the peptolysing action of the tryptic component of papain. Thus Laetrile does not replace pancreatic enzymes. However, the digestion of the natural nitriloside bearing foods, like papaya, sprouted legumes, grains and many other foods provide these serine-like enzymes, both the proteolytic and amylase, to fill in any deficiency of the endogenous ones. The importance of the fully functioning pancreas cannot be accentuated enough. Indeed, it's insufficiency is at the heart of the whole cancer problem, as well as a number of other paraneoplastic syndromes. Cancer is in fact merely the most severe of several diseases belonging to the pancreatic insufficiency syndrome. Since the generalized acceleration power of HCN on proteolytic enzymes has been well noted in the literature for some time, it may seem perplexing to find such wide spread dubiousness with regard to the nitrilosides (such as Laetrile) as having any potential use in cancer therapy. The glycoproteinaceous nature of the cancer pericellular membrane has been known for some time as well, and was pointed out unambiguously by Krebs and Bartlett in 1949, and by Krebs et al in 1950 forward. But the information was met only by silence or blind resistance. Nature's solutions, apparently, did not inspire interest or faith. Finally, besides the non-toxicity of nitrilosides and their obvious cytoxity to the cancer cell, there are mechanisms for nitrilosides to inhibit cancer gluconeogenesis (See Gurchot, http://www.europa.com/~rsc/gurchot.htm). Furthermore, the laetrile/nitriloside metabolite thiocyanate can play a role in the formation of red blood cells. Both radicals are natural bactericides, and antihelminthic. Wherever people consume nitrilosides in abundance, we see general good health and vigor. They thrive. Indeed to us the evidence is overwhelming that HCN is an essential molecule or factor (accelerator) not only for optimal pancreatic function, but plays a diverse role in overall homeostasis. Therefore Krebs was scientifically justified to propose the nitrilosides as essential food factors (vitamin B-17). And beyond his original work with this unique food factor in cancer, his role...following John Beard, after whom Krebs proudly declared himself a "Beardian"...in establishing the unitarian nature of all cancers should receive its just recognition, and honor. Some Natural Sources for vitamin B-17 (nitriloside) All fruits seeds, except citrus Apple seeds Apricot kernel Peach kernel Pear seeds Plum etc. Nectarine (the flesh) Huckleberry Elderberry Blackberry Strawberry (wild) Raspberry Current Manioc Papaya Lima beans & sprouts Mung bean & sprouts Garbonzo (chickpeas) Vicia fava Lentils Some forms of garden peas Buckwheat Barley Millet Flax seed etc. Wheat grass Johnson Grass Bermuda Grass etc. Alfalfa sprouts chia sprouts mustard sprouts buckwheat lentil, all sprouts are very rich in nutrients and very supportive to proper pancreatic function for obvious reasons.